Formal synthesis of the bisbenzylisoquinoline alkaloid berbamunine by asymmetric substitution of chiral organolithium compounds.
نویسندگان
چکیده
Asymmetric alkylation of enantiomeric tetrahydroisoquinolyl oxazolines was achieved with 96-97% diastereoselectivity. Removal of the oxazoline chiral auxiliary and further transformations provide a straightforward synthesis of the two synthetic intermediates that were previously synthesized by resolution, and which comprise a formal synthesis of berbamunine by Ullman coupling.
منابع مشابه
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عنوان ژورنال:
- ARKIVOC : free online journal of organic chemistry
دوره 2011 Pt 5 شماره
صفحات -
تاریخ انتشار 2011